Those carrying out "sickening" acid attacks will "feel the full force of the law", says Amber Rudd as she launches an action plan.
Amber Rudd claimed an overhaul of current guidelines would ensure those who use noxious liquids as a weapon "feel the full force of the law".
"I am clear that life sentences must not be reserved for acid attack survivors," she wrote in The Sunday Times.
Plans to ensure acid and other corrosive substances can be classed as dangerous weapons are among the changes included in the shake-up.
The Government will also aim to put in place measures which restrict the sale of such substances by retailers.
The Home Office will work with police and the Ministry of Justice to assess whether powers available to the courts, including sentencing, are sufficient.
Possession of acid or other corrosive substances with the intention to do harm can already be treated as possession of an offensive weapon under the Prevention of Crime Act, which carries a four-year maximum penalty.
Crown Prosecution Service's guidance to prosecutors will now be reviewed to ensure it makes clear that acid and other corrosive substances can be classed as dangerous weapons, and what is required to prove intent.
The Poisons Act 1972 will be assessed to consider if it should cover more harmful substances, while retailers will be asked to agree to measures to restrict sales of acids and other corrosive substances.
New guidance will also be issued to police on preventing attacks, searching potential attackers for harmful substances and responding to victims at the scene.
More than 400 acid or corrosive substance attacks were carried out in the six months up to April 2017, according to figures from 39 forces in England and Wales.
Bleach, ammonia and acid were the most commonly used substances, the Home Office said.
In an earlier statement, Ms Rudd said: "Acid attacks are horrific crimes which have a devastating effect on victims, both physically and emotionally.
"It is vital that we do everything we can to prevent these sickening attacks happening in the first place.
"We must also ensure that the police and other emergency services are able to respond as effectively as possible, that sentences reflect the seriousness of the offences and victims are given the immediate support they need."
Sarah Newton, minister for crime, safeguarding and vulnerability, will outline the Government's strategy in the Commons on Monday.