Jimmy Gopperth will line up alongside John Cooney at half back with ex Gonzaga College SJ scrum-half Cooney set to make his 25th appearance in Leinster colours at the Stadio Di Monigo (kick-off 2pm Irish time).
Noel Reid partners Brendan Macken at centre, with the experience of Australian international Lote Tuqiri joining St Mary's College duo Darragh Fanning and Darren Hudson in the back three.
Up front, Ireland prop Michael Bent starts in a front row which includes Aaron Dundon - a try-scorer in the province's 23-19 victory away to the Dragons last time out - and Martin Moore who makes his 15th appearance for Leinster.
In the second row, Tom Denton partners Quinn Roux with Rhys Ruddock (in what will be his 67th cap) joining number eight Leo Auva'a and skip Shane Jennings in the back-row.
Ireland scrum-half Eoin Reddan is named on a young replacements bench which includes seven Academy products.
REPLACEMENTS: (16-23) James Tracy, Jack O'Connell, Tadhg Furlong, Ben Marshall, Dominic Ryan, Eoin Reddan, Cathal Marsh, Collie O'Shea.