Clifford, one of the best ever prospects to emerge from the minor grade, scored , including 2-3 in a first half that saw him hit the net twice in the opening 15 minutes to effectively kill the game.
He also showed his vision with a sumptuous assist for the Kingdom's third goal, scored by Fiachra Clifford, which saw Kerry take a 3-8 to 0-5 lead in at half time.
Derry continued to battle and a Paddy Quigg penalty raised their spirits but it was just a brief reprieve.
David Clifford bolstered his tally and his growing reputation with two further goals to put clear water between the teams.
Speaking after the game to TG4, Clifford said: "Words can't describe it, I actually don't have a clue what to say.